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Clean & Clear Persa-Gel 10

Clean & Clear Persa-Gel 10

benzoyl peroxide 10%

OTC DrugClean & Clear Persa-Gel 10
Reviewed by Dr. Younghun Cho
78/100
Good

Reviewed by Dr. Younghun Cho, PharmD

This is a powerful and affordable acne treatment, but it loses points because the high strength causes significant irritation for many users, while lower strengths are often just as effective.

Pharmacist's Verdict

This is a powerful, maximum-strength spot treatment that works well on stubborn pimples for those with oily, non-sensitive skin, but its high concentration is often too irritating for widespread or daily use.

Ingredient Analysis

Benzoyl Peroxide (10%)

Details pending pharmacist review.

Carbomer

Details pending pharmacist review.

Disodium EDTA

Details pending pharmacist review.

Pros & Cons

Pros

  • Maximum over-the-counter strength (10%) is effective against stubborn, inflamed acne.
  • Works quickly to kill acne-causing bacteria and help unclog pores.
  • Widely available in most drugstores and very affordable.
  • Simple, fragrance-free formula focuses on the active ingredient.

Cons

  • Very likely to cause dryness, redness, and peeling, especially during the first few weeks.
  • Can bleach fabrics like towels, pillowcases, and clothing.
  • Not suitable for sensitive or dry skin types.
  • Studies show lower strengths (like 2.5% or 5%) can be just as effective with fewer side effects.

References

  1. 1.
    FDA Drug Label — BENZOYL PEROXIDE 5% Topical wash

    FDA DailyMed: BENZOYL PEROXIDE 5% Topical wash · FDA

  2. 2.
  3. 3.
    Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies.

    Kim HJ, Kim YH, International journal of molecular sciences, 2024 · PubMed

  4. 4.
    Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments.

    Podwojniak A, Tan IJ, Sauer J, et al., Journal of the European Academy of Dermatology and Venereology : JEADV, 2025 · PubMed

  5. 5.
    Dermatology: how to manage acne vulgaris.

    Leung AK, Barankin B, Lam JM, et al., Drugs in context, 2021 · PubMed

  6. 6.
    Treatments for Moderate-to-Severe Acne Vulgaris: A Systematic Review and Network Meta-analysis.

    Harper JC, Baldwin H, Choudhury SP, et al., Journal of drugs in dermatology : JDD, 2024 · PubMed

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