Dr.pharmacist
Pepto-Bismol

Pepto-Bismol

bismuth subsalicylate

OTC DrugPepto-Bismol
Reviewed by Younghun Cho

Pharmacist's Verdict

Pepto-Bismol is a reliable, multi-symptom remedy for mild digestive issues like indigestion and traveler's diarrhea, but its aspirin-like ingredient means it's not safe for everyone, especially children.

Ingredient Analysis

Bismuth Subsalicylate

Pros & Cons

Pros

  • Treats five common stomach issues: nausea, heartburn, indigestion, upset stomach, and diarrhea.
  • Works relatively quickly to coat the stomach and calm irritation.
  • Widely available over-the-counter and generally affordable.
  • Has both anti-inflammatory and mild antibacterial properties, which helps with traveler's diarrhea.

Cons

  • Can cause a harmless but surprising side effect: a temporary black tongue and/or black stools.
  • Contains a salicylate, so it must be avoided by people with aspirin allergies.
  • Should not be given to children or teenagers recovering from the flu or chickenpox due to the risk of Reye's syndrome, a rare but serious condition.
  • Can interact with blood thinners (like warfarin) and certain medications for diabetes or gout.

Safety Information

Warnings

Warnings Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert: Contains salicylate. Do not take if you are allergic to salicylates (including aspirin) taking other salicylate products Do not use if you have an ulcer a bleeding problem bloody or black stool Ask a doctor before use if you have fever mucus in the stool Ask a doctor or pharmacist before use if you are taking any drug for anticoagulation (thinning the blood) diabetes gout arthritis When using this product a temporary, but harmless, darkening of th…

Is Pepto-Bismol safe for you?

See pregnancy, interactions, and common concerns answered in our pharmacist safety FAQ.

Read safety review →

References

  1. 1.
    FDA Drug Label — Bismuth

    FDA DailyMed: Bismuth · FDA

  2. 2.
    FDA Drug Label — Pepto-Bismol

    FDA DailyMed: Pepto-Bismol · FDA

  3. 3.
    Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report.

    Riddle MS, Connor BA, Beeching NJ, et al., Journal of travel medicine, 2017 · PubMed

  4. 4.
    Bismuth subsalicylate: history, chemistry, and safety.

    Bierer DW, Reviews of infectious diseases, 1990 · PubMed

  5. 5.
    Bismuth Subsalicylate.

    , 2006 · PubMed

  6. 6.
    Helicobacter pylori infection.

    Suerbaum S, Michetti P, The New England journal of medicine, 2002 · PubMed