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Delsym 12 Hour
Pharmacist Safety Review

Is Delsym 12 Hour Safe?

Generic: dextromethorphan polistirex

Reviewed by Younghun ChoLast reviewed April 20, 2026

Generally yes, Delsym 12 Hour is safe for most adults and children over 4 when used according to the label directions. It effectively relieves coughs due to colds or flu. However, like all medications, it can have side effects and interact with other drugs, especially if misused or taken in excessive amounts.

Who Should Avoid or Consult First

  • Children under 4 years old
  • Individuals taking MAO inhibitors (a type of antidepressant)
  • People with a chronic cough from conditions like asthma, emphysema, or smoking, unless directed by a doctor
  • Pregnant or breastfeeding women should consult a doctor before use
  • People with severe liver disease

Common Side Effects

  • Drowsiness or dizziness — reported in some users, especially at higher doses.
  • Nausea or stomach upset — generally mild.
  • Constipation.
  • Headache.

Interactions to Watch For

MAO Inhibitors (e.g., phenelzine, selegiline)

Combining Delsym with these medications can lead to a serious condition called serotonin syndrome, which can be life-threatening.

SSRIs and SNRIs (certain antidepressants like fluoxetine, sertraline)

These combinations can increase the risk of serotonin syndrome, causing symptoms like confusion, rapid heart rate, and muscle rigidity.

Alcohol

Alcohol can increase the drowsiness and dizziness side effects of Delsym.

Other cough and cold medicines

Many other cold medicines contain dextromethorphan, so taking them together can lead to an accidental overdose.

People Also Ask

Can pregnant women take Delsym?

It is generally recommended that pregnant or breastfeeding women consult their doctor before taking Delsym 12 Hour. While studies haven't shown clear harm, it's best to be cautious and discuss any medication use with a healthcare provider during pregnancy or lactation.

Is Delsym safe for children?

Delsym 12 Hour is safe for children 4 years and older when dosed correctly. For children under 4, it should not be used. Always follow the dosing instructions on the label carefully based on the child's age.

What happens if I take too much Delsym?

Taking too much Delsym can lead to serious side effects including nausea, vomiting, dizziness, drowsiness, confusion, hallucinations, and rapid heart rate. In severe cases, it can cause respiratory depression or coma. If you suspect an overdose, seek immediate medical attention or call Poison Control.

Can I drink alcohol with Delsym?

No, it's best to avoid alcohol while taking Delsym 12 Hour. Both alcohol and dextromethorphan can cause drowsiness and dizziness, and combining them can intensify these effects, impairing your ability to drive or operate machinery safely.

Is Delsym addictive?

Delsym is not considered addictive in the same way as opioids, but misuse or abuse of high doses can lead to psychological dependence and serious health risks. It's important to use it only as directed for cough relief and not for recreational purposes.

Bottom Line

Delsym 12 Hour is a safe and effective cough suppressant for most people when used as directed. Always read the label, avoid combining it with alcohol or certain antidepressants, and never exceed the recommended dose to ensure safe use.

References

  1. 1.
    FDA Drug Label — foster and thrive 12 hour cough relief

    FDA DailyMed: foster and thrive 12 hour cough relief · FDA

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Educational content based on FDA labeling, published research, and pharmacist review. Not a substitute for individualized medical advice.