Is Xyzal Safe?
Generic: levocetirizine
Generally yes, Xyzal (levocetirizine) is considered safe for most adults and children over 6 years old when used as directed. It's an effective allergy medication, but it can cause drowsiness, especially when combined with alcohol or other sedating medications. Always follow the dosing instructions carefully.
Who Should Avoid or Consult First
- People with kidney disease
- Individuals who have had an allergic reaction to Xyzal, levocetirizine, or cetirizine
- People with trouble urinating or emptying their bladder
- Breastfeeding women
Common Side Effects
- Drowsiness
Interactions to Watch For
Drinking alcohol while taking Xyzal can significantly increase drowsiness and impair your ability to drive or operate machinery.
These medications can increase the drowsy effects of Xyzal, making it unsafe to drive or operate machinery.
People Also Ask
Is Xyzal safe during pregnancy?
If you are pregnant, it's important to consult a healthcare professional before using Xyzal. They can help determine if the benefits outweigh any potential risks for your specific situation.
Can I drink alcohol while taking Xyzal?
No, it is strongly recommended to avoid alcoholic drinks when taking Xyzal. Alcohol can significantly increase the drowsiness caused by Xyzal, which can be dangerous and impair your ability to perform tasks like driving.
What happens if I take too much Xyzal?
In case of an overdose, you should seek medical help immediately or contact a Poison Control Center right away. Taking more than the recommended dose can lead to increased side effects and potentially serious health issues.
Bottom Line
Xyzal is a safe and effective option for allergy relief for many, but be mindful of its potential to cause drowsiness and avoid alcohol or other sedating medications while using it. If you have kidney issues or difficulty urinating, consult your doctor first.
References
- 1.FDA Drug Label — Xyzal Allergy 24HR
FDA DailyMed: Xyzal Allergy 24HR · FDA
- 2.FDA Drug Label — levocetirizine dihydrochloride
FDA DailyMed: levocetirizine dihydrochloride · FDA
- 3.Efficacy of different oral H(1) antihistamine treatments on allergic rhinitis: a systematic review and network meta-analysis of randomized controlled trials.
Hong D, Weng J, Ye M, et al., Brazilian journal of otorhinolaryngology, 2023 · PubMed
- 4.Efficacy and safety of montelukast-levocetirizine combination therapy in combined allergic rhinitis and asthma syndrome: a systematic review and meta-analysis.
Shao M, Sun J, Zheng Q, The Journal of asthma : official journal of the Association for the Care of Asthma, 2025 · PubMed
- 5.Treatment of acute urticaria: A systematic review.
Badloe FMS, Grosber M, Ring J, et al., Journal of the European Academy of Dermatology and Venereology : JEADV, 2024 · PubMed
- 6.Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.
Devillier P, Roche N, Faisy C, Clinical pharmacokinetics, 2008 · PubMed
Want the full pharmacist analysis?
See full review of XyzalEducational content based on FDA labeling, published research, and pharmacist review. Not a substitute for individualized medical advice.